Monoamine metabolites in lumbar CSF: The question of their origin in relation to clinical studies
Identifieur interne : 005408 ( Main/Exploration ); précédent : 005407; suivant : 005409Monoamine metabolites in lumbar CSF: The question of their origin in relation to clinical studies
Auteurs : E. Garelis [Canada] ; S. N. Young [Canada] ; S. Lal [Canada] ; T. L. Sourkes [Canada]Source :
- Brain Research [ 0006-8993 ] ; 1974.
Abstract
Abstract: The sources of homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) and 5-hydroxyindoleacetic acid (5HIAA) in lumbar CSF of man are discussed. Although HVA in lumbar CSF is derived from the brain, and MHPG seems to be mainly from the spinal cord, the origin of 5HIAA is uncertain. The evidence for and against a brain contribution to 5HIAA of the lumbar CSF is evaluated. It is concluded that the brain can contribute 5HIAA to lumbar CSF under some circumstances. Measurement of 5HIAA concentrations in lumbar CSF can be of clinical value in detecting changes of 5-hydroxytryptamine (5HT) metabolism in the CNS if the changes are general throughout the CNS.
Url:
DOI: 10.1016/0006-8993(74)90562-9
Affiliations:
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Garelis</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory of Neurochemistry, Department of Psychiatry, McGill University, Montreal, Que.</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Young, S N" sort="Young, S N" uniqKey="Young S" first="S. N." last="Young">S. N. Young</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory of Neurochemistry, Department of Psychiatry, McGill University, Montreal, Que.</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Lal, S" sort="Lal, S" uniqKey="Lal S" first="S." last="Lal">S. 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Although HVA in lumbar CSF is derived from the brain, and MHPG seems to be mainly from the spinal cord, the origin of 5HIAA is uncertain. The evidence for and against a brain contribution to 5HIAA of the lumbar CSF is evaluated. It is concluded that the brain can contribute 5HIAA to lumbar CSF under some circumstances. Measurement of 5HIAA concentrations in lumbar CSF can be of clinical value in detecting changes of 5-hydroxytryptamine (5HT) metabolism in the CNS if the changes are general throughout the CNS.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Garelis, E" sort="Garelis, E" uniqKey="Garelis E" first="E." last="Garelis">E. Garelis</name></region><name sortKey="Lal, S" sort="Lal, S" uniqKey="Lal S" first="S." last="Lal">S. Lal</name><name sortKey="Sourkes, T L" sort="Sourkes, T L" uniqKey="Sourkes T" first="T. L." last="Sourkes">T. L. Sourkes</name><name sortKey="Young, S N" sort="Young, S N" uniqKey="Young S" first="S. N." last="Young">S. N. Young</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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